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Faculty Research Areas

Molecular Cell Biology & Molecular Genetics

Dellaire, G. Nuclear structure and cancer biology; chemotherapy resistance and cancer biomarkers; CRISPR genome engineering; the role of nuclear organization in DNA repair, tumour suppression, and cell cycle control; genome instability and pre-mRNA splicing; zebrafish as a novel animal tumour model.
Dobson, M. J. Yeast and Mammalian Molecular Genetics
Duncan, R. Protein-mediated cell-cell membrane fusion during viral infections and muscle cell differentiation; viral fusion protein structure and function; cellular pathways involved in cell-cell fusion; exosomes and nonenveloped virus transmission; oncolytic viruses for tumour therapy.
Kramer, J. M. Epigenetics and chromatin in brain function
Marignani, P. A. Tumour suppressors, Cancer metabolism, Metabolome wide analysis, Signal Transduction, Animal models of human disease, Pre-clinical drug studies, Drug discovery, Whole genome manipulation, Stem cell biology, Epigenetic marks.
McMaster, C. R. Genetics and chemical genetics to identify drug targets and drugs for unmet medical needs
Ro, H.-S. Role of chronic inflammation in cancer and metabolic diseases
Rosen, K. V. Cancer, Cell Death, Cell Signalling
Singer, R. A. Yeast Chromatin and Membrane Dynamics
Too, C. K. L. Polypeptide and Steroid Hormone Action: Tumour Growth/Apoptosis
van der Spoel, A. C. Biochemistry and cell biology of inherited neurodegenerative diseases. Intracellular traffic of proteins and glycosphingolipids.
Waisman, D. M. Mechanisms of Tumor Growth, Invasiveness and Metastases

Comparative Genomics, Proteomics & Molecular Evolution

Archibald, J. M. Genome Evolution, Endosymbiosis, Molecular Phylogeny
Blouin, C. Protein Evolution and Folding
Cohen, A.M. Development and application of mass spectrometry techniques in proteomics and metabolomics
Doolittle, W. F. Genomics, Molecular Phylogeny, Gene Transfer
Gray, M. W. Protist Genomics, Mitochondria, Ribosomes
Liu, P. X.-Q. Intein-catalyzed protein splicing and applications in recombinant protein engineering, site-specific modification, peptide cyclization, and artificial spider silks
Roger, A. J. Genome, Organelle and Protein Evolution
Slamovits, C. H. Molecular biology and evolution of microbial eukaryotes

Structure, Function & Metabolism of Biomolecules

Bearne, S. L. Enzyme Catalysis and Inhibition, Protein Structure and Function, Chemical Biology
Ewart, K. V. Proteostasis, Amyloid Formation and Cold Adaptation
Kane, D. A. Exercise metabolism, mitochondria, monocarboxylate metabolism
Karten, B. Cholesterol Metabolism in the Brain, intracellular cholesterol trafficking, mitochondrial cholesterol
Kienesberger, P. C. My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal energy metabolism.
Langelaan, D.N. Structural biology, protein-protein interactions, cellular signalling, and protein engineering
McLeod, R. S. Apolipoprotein B, adiponectin and fatty acids: Structure, Function
Pulinilkunnil, T. Metabolic regulation of Autophagy in health and disease. Nutrient regulation of lysosome function. Biology of amino acid metabolism and signaling. Role of alpha-mannosyltransferase in glycosylation disorders
Rainey, J. K. Structural Biology and Biophysical Characterization of Proteins
Ridgway, N. D. Cell Biology of Cholesterol and Lipids

Undergraduate Education

Briggs, P. Undergraduate Biochemistry Lab Education
Ewart, K. V. Proteostasis, Amyloid Formation and Cold Adaptation