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Greg McCluskey

Ph.D. (Biochemistry)


B.Sc. (UNB), M.Sc. (Dalhousie)
Supervisor: Stephen L. Bearne
Research Area: Enzyme Catalysis and Chemical Biology

Tupper 9-J
902-494-1974
gregmccluskey@dal.ca


Keywords

enzymology, enzyme kinetics and inhibition, site-directed mutagenesis, protein & modification, UV-vis, AFM


Career Goals

My goal is to develop methods of treating illness using novel particles and delivery mechanisms. During my masters program I have designed a morpholino that represses the translation of AEBP1, a protein involved in many inflammatory diseases as well as breast cancer, significantly. The next goal is to deliver the morpholino to our model organism specifically to macrophages with a high delivery efficiency.


Research Interests

My current research interests involve the development of therapeutic drugs that can be administered efficiently. Many developments have been made in treating cancer, diabetes, and inflammatory diseases but most treatments are invasive and expensive. My main interest is in research of novel therapeutics and novel mechanisms for applying them. During my honours and post-graduate work I have learned many molecular and biochemical techniques such as primer and probe design, quantitative PCR, western blotting, embryonic morpholino microinjection, in vitro morpholino transfection, and am most recently becoming familiar with fluorescent microscopy.

Education

Bachelor of Science (2005-2009)
University of New Brunswick, Dept. of Biology
Ontogeny of matrix metalloproteinases and analysis of their role in extracellular matrix remodelling.

Master of Science (2009-2012)
Dalhousie University, Dept. of Biochemsitry and Molecular Biology
AEBP1 alters matrix signalling and is responsive to inflammation in the mammary gland

Ph.D. (2012-)
Dalhousie University, Dept. of Biochemistry and Molecular Biology

Awards & Professional Activities

Scholarships & Awards


Best poster: New Directions in Enzymology (2015) ASBMB 2015 Annual Meeting

Poster presentation award: first place (2014) IHRTP Graduate Student Research Day

Professional Activities


Gemcitabine Is a Competitive Inhibitor of Cytidine-5’-Triphosphate Synthase that Induces Enzyme Filament Polymerization (2015), ASBMB 2015 Annual Meeting

Mechanism of ammonia trafficking in the therapeutic target CTP synthase (2014) IHRTP Graduate Stduent Research Day

McCluskey G, Fitzpatrick C.M.M, and Crawford B.D. MMP11 is necessary for somite boundary remodeling and notochord elongation in the zebrafish (2009) AZUG's First Atlantic Zebrafish Research Symposium