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Seminars Archive 2010


Dr. John T. (Sean) Brosnan
Thursday, January 21, 2010
New Insights into Creatine Synthesis and Function

Dr. Tobias Kadi Karakach
Thursday, January 14, 2010
Measurement and Analysis of Multi-dimensional Biological Data

Dr. Barbara Karten
Thursday, January 07, 2010
Cholesterol Trafficking and Synaptic Vesicle Cycling in Niemann-Pick Type C Disease


Dr. Raymond T. Syvitski
Thursday, February 25, 2010
Biomolecular Structure, Function and Beyond with Magnetic Resonance Technologies

Professor M. Cynthia Goh
Thursday, February 18, 2010
Diffraction-based Sensing: From Measurement of Biomolecular Interactions to Applications in Medical Diagnostics

Ryan Holloway, Ph.D. Candidate
Thursday, February 11, 2010
The Role of Adipocyte Enhancer-Binding Protein 1 (AEBP1) in Mammary Gland Development and Tumourigenesis

Bruce Curtis, Ph.D. Candidate
Thursday, February 04, 2010
Endosymbiotic Gene Transfer in Nucleomorph Containing Protists


Graduate Student Symposium - 2010
Tuesday, March 30, 2010

Graduate Student Symposium Schedule
Tupper 14-B2
Tuesday March 30th

8:45-8:55Coffee & muffins (courtesy of Biochemistry & Molecular Biology)
Session 1 - Chair: Courtney Stairs
8:55-9:00Opening remarks
9:00-9:30Greg McCluskey (Ro lab) "A unique application of steric-block antisense oligomers in treating myotonic dystrophy type 1 is a step in the right direction." Discussion of: Wheeler, T. M. et al. (2009) Science 325: 336-339
9:30-10:00Dale Corkery (Dellaire lab) "Bridging the gap between nuclear architecture and embryonic stem cell pluripotency with Chd1." Discussion of: Gaspar-Maia, A. et al. (2009) Nature 460: 863-868.
10:00-10:30Marie-Laurence Tremblay (Rainey lab) "Sensing voltages: structure and hydration of lipid membranes by voltage sensing domains." Discussion of: Krepkiy, D. et al. (2009) Nature 462: 473-479
10:30-11:00Coffee Break (courtesy of Biochemistry & Molecular Biology)
Session 2 - Chair: Dale Corkery
11:00-11:30Javier Alfaro (Roger lab) "Establishing synchrony within a quorum of genetic oscillators." Discussion of: Danino, T. et al. (2010) Nature 463: 326-330.
11:30-12:00Mary McQuaid (Dobson lab) "Acetylation of histone H4 lysine 16 in aging cells - Evidence that the histone code dictates cellular lifespan." Discussion of: Dang, W. et al. (2009) Nature 459: 802-807.
12:00-12:30Barry Kennedy (Karten lab) "Sleep deprivation causes memory loss through upregulation of phosphodiesterase 4 and disruption of cAMP signalling in the mouse hippocampus." Discussion of: Vecsey, C. G. et al. (2009) Nature 461: 1122-1125.
12:30-1:30 Lunch (courtesy of DBSS) Room 9A-1
Session 3-Chair 1: Daniel Arsenault
1:30-2:00Courtney Stairs (Roger lab) "Prion proteins are susceptible to artificial selection in cell culture." Discussion of: Li, J. et al. (2010) Science 327: 869-872.
2:00-2:30Alison Suraci (McMaster lab) "Haploid Genetic Screens Rescue Stalled Host-Pathogen Biology Studies" Discussion of: Carette, J. E. et al. (2009) Science 326: 1231-1235.
Session 3-Chair 2: Mary McQuaid
2:30-3:00André Dubé (Ewart lab) "A switch between life or death- Phosphorylation state of H2AX determines apoptosis and survival decisions." Discussion of: Cook, P. J. et al. (2009) Nature 458: 591-596.
3:00-3:30Dan Arsenault (Ridgway lab) "Dual regulation of telomeres and gene expression through TERT-ribonucleoprotein complexes." Discussion of: Maida, Y. et al. (2009) Nature 461: 230-238.

William McDonald- M.Sc. Candidate
Thursday, March 25, 2010
Characterization of Novel Protein Partners of α4 Phosphoprotein

Mark Charman M.Sc. Thesis Defence
Thursday, March 25, 2010
Characterization of an Endosome to Mitochondria Cholesterol Import Pathway Mediated by MLN64

Yi Wang-Ph.D Thesis Defence
Wednesday, March 24, 2010
Engineering Inteins for Protein Splicing in cis and in trans by Rational Design and Directed Evolution

2010 Honours Student Seminars- Day 3
Friday, March 19, 2010
3:30 Introductory Remarks
3:35 - 3:45 Jennifer Onochie
Studies on Alpha 4 Phosphoprotein as a Negative Regulator of MCF-7 Cell Proliferation
3:50 - 4:00 Ishrat Jalal
Probing the Substrate Specificity of the Nucleotidylyltranferase Cps2L
4:05 - 4:15 Winston Tan
Determining PML Protein-Protein Interactions using a Yeast-2-hybrid System
4:20 - 4:30 Jessica Robinson
Characterizing the Role of Acetylcholinesterase in Embryonic Mouse Cardiomyocyte Proliferation and Differentiation
4:35 - 4:45 Myuran Thana
The Role of Presynaptic Ankyrin in the Stability and Formation of the Vertebrate Neuromuscular Junction
4:55 - 5:05 Tiam Feridooni
The Role of p53 in Dox-Induced Cardiomyopathy
5:10 - 5:20 Aaron Banks
Correlation of Flexibility in Type I Collagen Monomers with Thermodynamic Properties
5:25 - 5:35 Bhreagh Kennedy
Characterization of Cytidine 5′-Triphosphate Synthase from Bacillus subtilis

2010 Honours Student Seminars- Day 2
Thursday, March 18, 2010
3:30 Introductory Remarks
3:35 - 3:45 Tiffany Mailman
Glial Lipoproteins Restore Synapse Formation in the Presence of Cholesterol Biosynthesis Inhibitors
3:50 - 4:00 Westley Reinhart-McMillan
The Effects of Oxidative Stress on the Survival of NPC1-Deficient Human Neuroblastoma Cells
4:05 - 4:15 Cynthia Lapointe
Sub-cloning and Overproduction of Inosine 5′-Mono-phosphate Dehydrogenase from Escherichia coli
4:20 - 4:30 Jessica Wentzel
Analysis of 2μm Plasmid Inheritance
4:35 - 4:45 Tyler Mills
Nucleomorph Gene & Genome Structure in Cryptophyte Algae
4:55 - 5:05 Minji Kim
Stiffness Changes in Human Airway Smooth Muscle Cells with Down-Regulated Expression of Vimentin Intermediate Filaments
5:10 - 5:20 Peter Dixon
Characterization of a NOS1AP Isoform and Defining a Novel PTB-PDZ Interaction.
5:25 - 5:35 Yejin Yun
AEBP1 Expression is Regulated by Lipopolysaccharide via Activation of NF-κB and/or MAPK Signaling Pathways

2010 Honours Student Seminars-Day 1
Wednesday, March 17, 2010
3:30 Introductory Remarks
3:35 - 3:45 Jordan Yarr
Insertion of a Universally Forbidden Peptide into Saccharomyces cerevisiae iso-1 Cytochrome c Through Site Directed Mutagensis
3:50 - 4:00 April Saunders
Protein Interactions at the Yeast 2μm Plasmid Stability Locus
4:05 - 4:15 Grant Stevens
Insights into the Anaerobic Energy Metabolism of Mitochondrion-Related Organelles of the Opportunistic Parasite Blastocystis sp.
4:20 - 4:30 Lauren Dombowsky
The Role of Annexin A2 in Protein Carbonylation
4:35 - 4:45 Omar Ayaz
Investigation of a High-Level Expression System for Mammalian Cytochrome c
4:55 - 5:05 Helen Chuang
Plasmodium falciparum Acyl Carrier Protein: A Target for Anti-malarial Drugs
5:10 - 5:20 Amy Florian
Effect of Fish Bioactives on Adiponectin Secretion from 3T3-L1 Cells
5:25 - 5:35 Alan Wong
Domain M: A Lipid Sensing Domain of Phosphocholine Cytidylyltransferase α

Elke Uribe- Ph.D Thesis Defence
Tuesday, March 16, 2010
Binding Specificity and Recognition Roles of the Atlantic Salmon C-type Lectin

Elke Uribe- Ph.D Thesis Defence
Tuesday, March 16, 2010
Binding Specificity and Recognition Roles of the Atlantic Salmon C-type Lectin

Paul O'Connell, Ph.D. Candidate
Thursday, March 11, 2010
Landscaping the Tumour-Microenvironment: The Role of S100A10 in Tumour-Associated Macrophage Function

Christa Moore - Ph.D. Candidate
Thursday, March 04, 2010
Small Genomes, Big Ideas: Comparative Genomics of Nature's Smallest Nuclei


Marissa Leblanc- Ph.D. Candidate
Thursday, April 29, 2010
PIP Your Ride: Membrane Dynamics and Vesicular Trafficking

Julia Cottle-M.Sc. Thesis Defence
Friday, April 23, 2010
Investigation of the Acyl Carrier Protein Binding Partners SpoT and AidB

Kyle Phipps- Ph.D. Candidate
Thursday, April 22, 2010
The Dual Role of p11 in Cancer Progression

Terry Colbourne- M.Sc. Candidate
Thursday, April 15, 2010
Characterizing the Lipid Binding Functions of Oxysterol Binding Protein-Related Protein 4 (ORP4)

Alexi Surette- Ph.D. Candidate
Thursday, April 08, 2010
Role of S100A10 in Endothelial Cell Mediated Fibrinolysis

Carolyn-Ann Robinson - M.Sc. Candidate
Thursday, April 01, 2010
Oxysterol Binding Protein Phosphorylation Acts as a Switch for Intracellular Localization


Dr. Anastasios (Tasos) Tsaousis & Marie Currie, Postdoctoral Fellow
Thursday, May 27, 2010
The Mysterious Organelle of Blastocystis sp.: Implications for the Evolution of Mitochondria

Dr. Jane E. Jackman
Thursday, May 20, 2010
Putting it in Reverse: Widespread Roles for 3'-5' Nucleotide Addition in Biology

Dr. Paul Liu
Thursday, May 13, 2010
Protein Splicing Inteins: Functional and Evolutionary Versatilities

Alison Suraci- M.Sc. Candidate
Thursday, May 06, 2010
Nuclear Localization of Rate-Determining Step in Phosphatidylcholine Synthesis: More Important than DNA?!


David Smith- Ph.D Candidate
Thursday, June 24, 2010
The Evolution of Genome Architecture: Insights from Green-Algal Organelle DNA

Peter Murphy-Recipient of the 2009/2010 Doug Hogue Award
Thursday, June 17, 2010
Exploring the Mechanisms of Acyl Carrier Protein Interactions and Acyl Transfer

Jordon Pinder-Ph.D. Candidate
Thursday, June 10, 2010
Multiple Roles for Sumoylation in Maintenance of the Parasitic Yeast Plasmid

Alison Suraci - M.Sc. Thesis Defence
Wednesday, June 09, 2010
The Role of PCT1 Phosphorylation in the Regulation of Nuclear Localization and Phosphatidylcholine Synthesis


Paul O'Connell
Thursday, July 29, 2010
"Regulation of Plasmin Generation by S100A10 in Myeloid Cells"

Dr. Jane Hoover-Plow
Thursday, July 29, 2010
"Plasminogen Regulates SDF-1/CXCR4-mediated Hematopoietic Stem Cell Mobilization"


Marissa LeBlanc
Thursday, August 12, 2010
Regulation of Lipid Metabolism and Membrane Trafficking by the Oxysterol Binding Protein Superfamily Member Kes1

Terry Colbourne
Tuesday, August 10, 2010
"Characterizing the Lipid Binding Properties and Cytoskeletel Interactions of Oxysterol-Binding Protein-Related Protein 4 (ORP4)"

Patricia Mitchell
Friday, August 06, 2010
"Bioactive Acid Supplementation and Risk Factors for the Metabolic Syndrome"

Dr. Andrew Salter, Professor
Thursday, August 05, 2010
"Manipulating the Fatty Acid Composition of Animal Products: Can We Turn Bad Fat Good?"


Eunsoo Kim
Thursday, September 30, 2010
Evolution of Eukaryotic Microbes:
Exploring Novel Diversity and Biotic Associations

Dr. Sunny Hartwig
Thursday, September 23, 2010
"The Molecular Functions of Wilms' Tumour Suppressor 1 (WT1) in Nephron Progenitor Stem Cells"

Dr. Jan Rainey
Thursday, September 16, 2010
"Structure-Function Correlation for Apelin and its Cognate G-protein Coupled Receptor"

Dr. Jorge Filmus
Thursday, September 09, 2010
"The Role of Glypicans in the Regulation of Hedgehog Signaling"


Dr. Ashley Cowart
Thursday, October 28, 2010
"Bioactive Lipids in Metabolic Disease: Regulation of Synthesis by Dietary Fatty Acids"

Dr. Lori Frappier
Thursday, October 21, 2010
"Host Interactions of Epstein-Barr Nuclear Antigen 1 (EBNA 1)"

Dr. Steven Smith
Thursday, October 14, 2010
"Molecular Basis of E2A-PBX1 Induced B-cell Leukemia:
Structural and Functional Studies of the E2A-CBP Interaction"

Dr. Christian Blouin
Thursday, October 07, 2010
"Capturing the Evolution of the
Tertiary Structure of Proteins"


Dr. Evgeny Pavlov
Thursday, November 25, 2010
"Role of Inorganic Polyphosphate and Polyhydroxybutyrate in Ion Transport of Mammalian Mitochondria"

Tyler Reddy, PhD Candidate & Ryan Marko, Honours Co-op Student
Thursday, November 18, 2010
"Molecular Dynamics Simulations of the FGFR3 Transmembrane Domain and the Spitz-Rhomboid System."
"Inhibitors of an Enzyme Involved in Fatty-Acid Metabolism: Synthesis and Evaluation"

Dr. Stephen Bearne
Thursday, November 04, 2010
"Movement of Substituents Around Stereocenters During Catalysis by Racemases and Epimerases"


Dr. Jessica Leigh - Patrick Prize Recipient
Thursday, December 09, 2010
"A New Notion of Congruence and Implications for Prokaryotic Evolution"

Dr. Pierre Lavigne
Thursday, December 02, 2010
Structural Biology of the c-Myc/Max/Mad/Miz-1 Network