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Seminars Archive 2013


Dr. Petra Kienesberger
Thursday, January 31, 2013
Lipid Hydrolases at the "Heart" of Health & Disease

Mary McQuaid
Thursday, January 24, 2013
Puzzling Persistence: Investigating the DNA Sequences and Proteins Encoded by the 2µm Plasmid that Mediate its Remarkable Maintenance

Dr. Carrie Shemanko
Thursday, January 17, 2013
Molecular Insight into Prolactin-Mediated Chemotherapy Drug Resistance

Marie-Laurence Tremblay
Thursday, January 10, 2013
The Exquisite and Surprising Modularity of Spider Wrapping Silk


Dr. Grant Brown
Thursday, February 21, 2013
Genome-scale analysis of Protein Dynamics During DNA Replication Stress in S. cerevisiae

Re-localization of proteins is a hallmark of the DNA damage response. We have used high-throughput microscopic screening of the yeast GFP fusion collection to develop a systems-level view of protein re-organization following drug-induced DNA replication stress. Changes in protein localization and abundance reveal drug-specific patterns of functional enrichments. Classification of proteins by sub-cellular destination allows the identification of pathways that respond to replication stress. We analyzed pairwise combinations of GFP fusions and gene deletion mutants to define and order two DNA damage responses. This method identifies response pathways that were not detected in genetic and protein interaction screens, and can be readily applied to any form of chemical or genetic stress to reveal cellular response pathways.

Dale Corkery
Thursday, February 07, 2013
Understanding the Role of PRP4 Kinase in the Cellular Response to Taxanes


Ph.D. Thesis Defence - Eric Fisher
Thursday, March 28, 2013
Modulation of apolipoprotein B-100 degradation and secretion by hepatic protein quality control components

Dr. Khosrow Adeli
Thursday, March 28, 2013
Hepatic Autophagy in Regulation of Apolipoprotein B Degradation and VLDL Assembly

Honours Student Seminars
Friday, March 22, 2013
3:05 Allen Custance
3:20 Jeffrey Komar
3:35 Nick MacArthur
3:50 Heidi Wong
4:05 Niroshaathevi Arumuggam
4:20 Patrick Tillman
4:35 Ahmed Lutfi
4:50 Paalini Sathiyaseelan
5:05 Ain Adilliah Kamaludin

Honours Student Seminars
Thursday, March 21, 2013
3:05 Katherine Strynatka
3:20 Jae Ho Han
3:35 George Worthen
3:50 Mandy McConnell
4:05 Brent Young
4:20 Kristine Yarney
4:35 Sara Sparavalo
4:50 Thillaga Sathemany
5:05 Matthew Bertrand

Honours Student Seminars
Wednesday, March 20, 2013
3:35 Qinyan Song
3:50 Matthew Harty
4:05 Cynthia Tram
4:20 Da Young Lee
4:35 Hirad Feridooni
4:50 Cornelis Mutsaers
5:05 Matthew Taylor

Mitesh Nagar
Thursday, March 14, 2013
An Enzyme’s Obsession for the Transition State: Insight from Mandelate Racemase Catalysis

Graduate Student Symposium
Thursday, March 07, 2013
Recent Papers from Nature & Science


MSc Thesis Defence - Mandar Khanal
Friday, April 26, 2013
Inhibition of Prostate Cancer Biomarker α-Methylacyl-CoA Racemase (AMACR) By Novel Substrate-product Analogues

MSc Candidates - Nigel Chapman & Xinwei Liu
Thursday, April 25, 2013
Nigel Chapman
Structural Characterization of the Extracellular Region of the Apelin Receptor and Its Interaction with Apelin

Xinwei Liu
Phosphatidylinositol 4-phosphate is a Novel Ligand for Oxysterol-binding Proteins

MSc Thesis Defence - Samir Koirala
Tuesday, April 16, 2013
Hormonal Regulation of Carboxypeptidease-D Gene Transcription in Breast Cancer Cells

Barry Kennedy
Thursday, April 11, 2013
Endosome to Mitochondrion Cholesterol Trafficking Influences Energy Metabolism in Niemann-Pick Type C Disease

Dr. Timothy Shutt
Thursday, April 04, 2013
Mechanistic Insight into the Regulation of Stress Induced Mitochondrial Hyperfusion


2011 Patrick Prize Award Seminar - Dr. Ryan Gawryluk
Thursday, May 30, 2013
Insights into Mitochondrial Evolution Derived from Comparative Proteomics

Dr. Jason Bielas
Thursday, May 23, 2013
Mechanism and Clinical Utility of Nuclear and Mitochondrial DNA Mutations in Cancer

Dr. Susan Howlett
Thursday, May 16, 2013
The Ageing Heart: Influence of Sex and Frailty

Dr. Sebastián Najle
Thursday, May 09, 2013
Gene Discovery and Characterization of Sterol Metabolism Enzymes in Tetrahymena Thermophila

Dr. Suzanne Currie
Thursday, May 02, 2013
Heat Shock Proteins, Hormones and Hierarchies: Fish as a Model to Understand Integrated and Flexible Response to Stress


PhD Thesis Defence - Christa Moore
Thursday, June 06, 2013
Comparative Genomics of Endosymbiotically-derived Organelles in Cryptophyte Algae

Dr. Gertraud Burger
Thursday, June 06, 2013
From the Most Bacteria-like to the Most Derived Mitochondrial Genomes Known Today


Dr. Trevor Lawley
Thursday, July 25, 2013
Emergence and global spread of healthcare-associated Clostridium difficile


MSc Thesis Defence - Xinwei Liu
Thursday, August 15, 2013
Xinwei Liu, BSc (Honours)
The Study on Oxysterol-binding Protein (OSBP) and Related Protein 9 (ORP9) Ligands: Sterols and Phosphatidylinositol 4-Phosphate


Dr. Michael Gray
Thursday, September 19, 2013
The Pre-Endosymbiont Hypothesis: An Updated Perspective on the Origin of Mitochondria

Dr. W. Ford Doolittle
Thursday, September 12, 2013
The ENCODE Project and the Meaning of "Function" in Biology and Biomedical Research


Dr. Roger McLeod
Thursday, October 31, 2013
Structural and Cellular Determinants of Hepatic Apolipoprotein B Metabolism

Dr. Tyler Reddy
Thursday, October 24, 2013
Biophysical Characterization of Full-Scale Influenza Virions, Dengue Virions, and Class III Viral Fusion Proteins

Dr. John Allingham
Thursday, October 17, 2013
Scratching the Surface on the Unusual Kinesin Motors in Human Fungal Pathogens

2012 Patrick Prize Seminar
Thursday, October 10, 2013
Dr. David Langelaan
Structure-function Studies Towards Understanding the Molecular Basis of E2A-PBX1 Induced B-cell Leukemia

Dr. Jana Sawynok
Thursday, October 03, 2013
Analgesics and Compartments. Where Do Drugs Act and Why Do We Need To Know?


Dr. Jim Omichinski
Thursday, November 28, 2013
Structural Characterization of Acidic Transactivation Domains from Transcriptional Regulatory Proteins Bound to TFIIH and Ubiquitin: Bringing Order to Disorder and Connecting Activation to Degradation.

Dr. Michael Ladomery
Thursday, November 21, 2013
WT1 Mutants Reveal SRPK1 to be a Novel Downstream Angiogenesis Target by Altering VEGF Splicing

Elizabeth Lake
Thursday, November 21, 2013
Role of Deubiquitination in Hepatic Apolipoprotein B Metabolism

Dr. Zemin Yao
Thursday, November 14, 2013
Homeostatic Regulation of apoB and Hepatic Triglyceride Metabolisms Through p62/Nrf2 Activation

Dr. Lawrence McIntosh
Thursday, November 07, 2013
Regulation of ETS Transcription Factors: Dynamic Sequences Provide Routes to Specificity


Dr. Eileen Denovan-Wright
Thursday, December 19, 2013
Exploring the Potential of Cannabinoids for Huntington's Disease

Dr. Younes Anini
Thursday, December 12, 2013
Ghrelin Signaling in Obesity and Insulin Resistance

Dr. Patrick Lee
Thursday, December 05, 2013
Viral Oncotherapy: In the End, it All Comes Down to Immunology