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Seminars Archive 2018


Dr. Derek Wilson
Wednesday, January 31, 2018
Linking Protein Conformational Dynamics with 'Real World' Drug Development
in Neurodegenerative Disease and Cancer


Dr. Gilbert Walker
Wednesday, February 14, 2018
Hydrophobic hydration

The interactions of hydrophobes with water, each other and surfaces drives many interesting processes, ranging from protein collapse, ligand binding and cellular attachment. Hydrophobe size matters, and there appears to be a fundamental transition from volume to surface area control of the hydrophobic hydration energies as size increases. I will illustrate how the macromolecule structure change is induced at these different length scales, with examples taken from single proteins, amyloids, polymers, and their surfaces. Finally, I will give examples of applications of these concepts to create materials for biodiagnostics and biofouling control.

Dr. Brendan Leung
Wednesday, February 07, 2018
Towards disease-on-a-dish: applications of microtissues and micropatterning technologies in advanced culture and assay platforms


Honours Student Research Presentations 2018
Wednesday, March 28, 2018
Honours Student Research Presentations 2018

Dr. Andrew M. Gulick
Friday, March 23, 2018
Multiple Strategies for Iron Acquisition: Biosynthesis of Siderophores using Assembly Lines or the Old Fashioned Way

Ph.D. Thesis Defence - Gregory D. McCluskey
Thursday, March 22, 2018
Investigation of Inhibition, Filament Formation, and Inter-Domain Ammonia Channelling of CTP Synthase

Dr. Christopher Beh
Wednesday, March 21, 2018
Membrane In - Membrane Out: Coordinating Transport to the Cell Membrane

Ph.D. Thesis Defence - Antonietta Pietrangelo
Tuesday, March 20, 2018
ORP4 is a Phospho-regulated Lipid Binding Protein Required for Cell Growth and Maintenance of TGN Morphology

Graduate Student Symposium
Wednesday, March 14, 2018
Biochemistry 5910.06

Dr. Lewis Kay, 2017 Canada Gairdner International Laureate
Wednesday, March 07, 2018
NMR Why Bother? Studies of the p97 Molecular Machine Provide an Answer


Dr. Gregory Steinberg
Wednesday, April 18, 2018
Cellular energy sensing and metabolism: implications for treating diabetes

2016 Patrick Prize Award Seminar - Dr. Mitesh Nagar
Wednesday, April 11, 2018
Finding keys to the “PAD”lock: Unraveling the regulation of Protein Arginine Deiminases

Dr. Robert Beiko
Wednesday, April 04, 2018
Mining Antimicrobial-Resistance Genes From Metagenomic Data


Jonghwa (Kyle) Lee, Ph.D. Candidate
Wednesday, May 23, 2018
The role of phosphatidylcholine in lipid droplet biogenesis and lipoprotein secretion

Sarah Shah & Michael McPhee, M.Sc. Candidates
Wednesday, May 16, 2018
Sarah Shah
“The mitochondrial genome of Blastocystis sp. isolated from the Oriental cockroach”


Michael McPhee
“Understanding the role of phosphatidylcholine biosynthesis in cancer cells.”

Macpherson Seminar
Monday, May 14, 2018


10:00 a.m.

Discovery and development of Selonsertib, a first in class inhibitor of ASK1 for the treatment of nonalcoholic steatohepatitis

Dr. David Breckenridge

Senior Director of Biology, Gilead Sciences Inc.
4:00 p.m.

Three short stories on survival in the age of CRISPR/Cas9

Dr. David Edgell

Acting Chair, Department of Biochemistry, Western University

Dr. L. B. Macpherson taught biochemistry at Dalhousie University for sixteen years and played a major role in the development of the Medical School.


Saki Sultana, Ph.D. Candidate
Wednesday, June 27, 2018
Understanding the biological role of beta-glucosidase 2 (GBA2), a gene mutated in neurological disorders

Dr. Jamie Kramer
Monday, June 25, 2018
“Epigenetic regulators in learning and memory”

Simiao (Michelle) Lu, Ph.D. Candidate
Wednesday, June 20, 2018
“A computational study to explore the conformational space of amyloid-beta”

Pooja Srinivasan, M.Sc. Candidate & Purvi Trivedi, Ph.D. Candidate
Wednesday, June 13, 2018
Pooja Srinivasan, M.Sc. Candidate

“Entropic effects on proline racemase catalysis”


Purvi Trivedi, Ph.D. Candidate

“Nutritional regulation of Transcription Factor EB (TFEB) in the heart”

Anamika Sulekha, Ph.D. Candidate
Wednesday, June 06, 2018
Investigation into the initiation of aciniform silk fibrillogenesis


Dr. Matt Field
Wednesday, July 04, 2018
“Comparison of Predicted and Actual Consequences of Missense Mutations: Implications for Personalized Medicine”


M.Sc. Thesis Defence, Pooja Srinivasan
Wednesday, August 22, 2018
“A study on the importance of an intact-ring structure in proline racemase catalysis”

Ph.D. Thesis Defence - Iman A. Khan
Tuesday, August 21, 2018
“Molecular mechanisms of ErbB2-driven three-dimensional breast tumor growth”

M.Sc. Thesis Defence, Michael McPhee
Tuesday, August 14, 2018
“An investigation of phosphoregulation and the role of CTP:phosphocholine cytidylyltransferase alpha in promoting ras-induced malignant transformation of intestinal epithelial cells.”

M.Sc. Thesis Defence, Sarah Shah
Tuesday, August 07, 2018
“The Genome of Blastocystis sp. Isolated from the Oriental Cockroach”


Dr. Andrew M. Gulick
Wednesday, September 26, 2018
“Iron Acquisition in Bacterial Pathogens: Structural and Functional Studies of Siderophore Biosynthesis”

Dr. Jennifer Schleit, Director of Molecular Genetics & Christine Davies, CGC and Genetic Services Consultant
Wednesday, September 19, 2018
“Understanding Genetic Variant Interpretation: Current Methods and Future Directions”


Dr. Yassine El Hiani
Wednesday, October 31, 2018
“Role of TRPM2 ion channel in breast cancer pathogenesis and chemoresistance”

Dr. Nikhil Thomas
Wednesday, October 17, 2018
“Bacterial modulation of virulence gene expression: flipping the switch towards pathogenesis”

Dr. Gareth Lim
Wednesday, October 10, 2018
“Determining the 14-3-3zeta interactome to understand adipocyte development”

Dr. Eva Nowack
Wednesday, October 03, 2018
“Gaining control over a bacterial endosymbiont – The long way from endosymbiont to organelle”


Ph.D. Thesis Defence - Sergio Andrés Muñoz Gómez
Wednesday, November 28, 2018
“The anatomical and phylogenetic nature of the first mitochondrial ancestor”

Dr. André Schneider
Wednesday, November 28, 2018
“Mitochondrial biogenesis in trypanosomatids: variations of a theme or fundamentally different?”

Honours Student Research Presentations 2018
Wednesday, November 21, 2018
4:10 – 4:20 pm - Xiaoyi Ma
Neuron Growth on Collagen/Recombinant Spider Silk Films

4:25 – 4:35 pm - Kathleen Vergunst
Characterization of the Interaction Between Microphthalmia-associated Transcription Factor (MITF) and CBP/p300.

4:40 – 4:50 pm - Keira Durnin
Genomic Insights into Nephromyces: a Novel Lineage of the Apicomplexa

Dr. David Smith, Student Research Day Guest Speaker
Wednesday, November 14, 2018
Events Include:
Biochemistry & Molecular Biology Students - Meet with Dr. David Smith
12:00 - 12:50 p.m. Tupper Bldg. Rm. 9-A1

Workshop on Popular Science Writing with Dr. David Smith
1:00-2:00 p.m. CHEB C264

Research Poster Presentations
2:00-2:45 p.m. Location - CHEB C140

Undergraduate & Graduate Three Minute Thesis
3:00-3:50 p.m. CHEB C264

Keynote Speaker: Dr. David Smith
“Stranger things: the green algal organelle genome edition”
4:00 to 5:00 p.m. - Theatre A, Tupper Medical Bldg. (Halifax) and Room 102, DMNB (Saint John, NB)

For more information contact: Shannon Sibbald - Shannon.sibbald@dal.ca

Sergio Andrés Muñoz-Gómez - Recipient of the 2017/2018 Doug Hogue Award
Wednesday, November 07, 2018
“The nature of the first mitochondrial ancestor”


Dr. Dipali Sharma
Wednesday, December 05, 2018
“Mechanistic Links Underlying Obesity-Breast Cancer Connection: Insights and Strategies.”